ClinVar Pathogenic Variants

Clinical

Clinically curated pathogenic variant database with detailed phenotype associations.

45 GB1,250,000 data itemsLevel 2Updated 2026-01-20

Clinical variantsPathogenicityACMG classification

Schema preview

Schema Verified

Column	Type	Description	Nullable
sample_id	VARCHAR(50)	Unique sample identifier	No
patient_age	INTEGER	Patient age	Yes
diagnosis	VARCHAR(200)	Diagnosis code	No
gene_expression	ARRAY<FLOAT>	Gene expression vector	No
variant_calls	JSON	Variant call information	Yes
collection_date	DATE	Sample collection date	No

Sample data

Showing 3 mock records

sample_id	patient_age	diagnosis	gene_expression	variant_calls	collection_date
SMP-001	45	C34.1	[0.23, 0.87, ...]	{...}	2025-06-15
SMP-002	62	C50.9	[0.45, 0.12, ...]	{...}	2025-07-22
SMP-003	38	C18.0	[0.78, 0.34, ...]	{...}	2025-08-10

Usage guide

Data access

This dataset must be accessed in a secure TEE environment. Create a new workspace via Projects; the dataset will be automatically mounted into your Jupyter environment.

Compliance statement

This dataset has passed IRB review. Use must comply with the Public Domain license/terms. Do not attempt re-identification or use the data for insurance underwriting or similar purposes.

Citation

@dataset{ds-004,
  title = {ClinVar Pathogenic Variants},
  provider = {NCBI},
  year = {2025},
  license = {Public Domain}
}

Billing model

Per data item pricing

$0.0003/data item/30 days

You are billed for the number of data items you access. Each data item is licensed for 30 days, with unlimited reads during the license window.

Metering policy

•Unique Data Item: billed once per unique data_id; repeat reads within 30 days are not charged again
•Auto-renew: after the license expires, continued access automatically renews the data item license
•Volume discounts: tiered discounts apply for purchases over 1M data items

100k data items / 30 days$30

Full dataset / 30 days$375

Provider

NCBI

Public Domain